This presentation outlines the current role of ultrasound in the imaging of genetic syndromes. Learn how to follow a systematic approach for the early recognition of sonographic features that raise suspicion for chromosomal and single gene disorders in routine prenatal ultrasound. The difference between major structural anomalies and soft markers, first trimester vs second/third trimester detection and how ultrasound is used in conjunction with NIPT and CMA/ whole exome sequencing will be explored. Case examples will focus on the most common conditions of Trisomy 21, 18, 13, Turner’s Syndrome and then some less common genetic conditions.